促性腺激素释放激素对大鼠胚胎大脑皮质神经元突起生长及神经丝蛋白表达的神经营养作用。
Neurotrophic effects of GnRH on neurite outgrowth and neurofilament protein expression in cultured cerebral cortical neurons of rat embryos.
作者信息
Quintanar J Luis, Salinas Eva
机构信息
Laboratory of Neurophysiology, Department of Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Col. Ciudad Universitaria, CP 20100, Aguascalientes, Ags, México.
出版信息
Neurochem Res. 2008 Jun;33(6):1051-6. doi: 10.1007/s11064-007-9549-9. Epub 2007 Dec 20.
The presence of GnRH receptor in cerebral cortical neurons of rat embryos and adult rats has been described. In this work, we studied the effects of GnRH on outgrowth and length of neurites and cytoskeletal neurofilament proteins expression (NF-68 and NF-200 kDa) by immunoblot of cultured cerebral cortical neurons of rat embryos. Our results show that GnRH increases both outgrowth and length of neurites accompanied by an increase in neurofilaments expression. It is conceivable that GnRH plays a role in neuronal plasticity parallel to its gonadal function.
大鼠胚胎和成年大鼠大脑皮质神经元中促性腺激素释放激素（GnRH）受体的存在已有相关描述。在本研究中，我们通过对大鼠胚胎大脑皮质神经元培养物进行免疫印迹，研究了GnRH对神经突生长、长度以及细胞骨架神经丝蛋白表达（NF - 68和NF - 200 kDa）的影响。我们的结果表明，GnRH可增加神经突的生长和长度，同时伴随着神经丝表达的增加。可以想象，GnRH在与其性腺功能平行的神经元可塑性中发挥作用。
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