Wajda Rudi, Zirkel Jürgen, Schaffer Tanja
Lipoid GmbH, Ludwigshafen, Germany.
J Med Food. 2007 Dec;10(4):731-4. doi: 10.1089/jmf.2006.254.
Commercial coenzyme Q(10) (CoQ(10)) and alpha-tocopherol (vitamin E) formulations often show poor intestinal absorption. Delivery of CoQ(10) and vitamin E was enhanced when used with a new formulation, NanoSolve (Lipoid GmbH, Ludwigshafen, Germany), as shown by an open, comparative monocenter, crossover study of 24 volunteers. Plasma CoQ(10) and vitamin E were determined from predose until +14 hours. To compare bioavailability, corrected maximum concentration, time to reach maximum concentration, and area under the curve from 0 to 14 hours were assessed. The NanoSolve test formulation contained 100 mg of CoQ(10) and 120 mg of vitamin E. The pure substances in hard gelatin capsules served as the reference. Although identical amounts of CoQ(10) and vitamin E were administered, absolutely higher serum concentrations of the active ingredients were achieved by the NanoSolve formulation than by the pure materials in gelatin capsules. The bioavailability of CoQ(10) increased fivefold after administration of the NanoSolve formulation, and the bioavailability of vitamin E was enhanced 10-fold both compared to the pure substances.
市售辅酶Q(10)（CoQ(10)）和α-生育酚（维生素E）制剂通常肠道吸收较差。一项针对24名志愿者的开放性、单中心、交叉对照研究表明，与一种新型制剂NanoSolve（德国路德维希港Lipoid GmbH公司）联合使用时，CoQ(10)和维生素E的递送得到增强。测定了给药前至给药后14小时的血浆CoQ(10)和维生素E水平。为比较生物利用度，评估了校正后的最大浓度、达到最大浓度的时间以及0至14小时的曲线下面积。NanoSolve测试制剂含有100毫克CoQ(10)和120毫克维生素E。硬明胶胶囊中的纯物质作为对照。尽管给予的CoQ(10)和维生素E量相同，但与明胶胶囊中的纯物质相比，NanoSolve制剂使活性成分的血清浓度绝对更高。给予NanoSolve制剂后，CoQ(10)的生物利用度提高了五倍，与纯物质相比，维生素E的生物利用度提高了10倍。
