Kuhn S M, Preiksaitis J, Tyrrel G J, Jadavji T, Church D, Davies H D
Department of Pediatrics, University of Calgary, Calgary, Alberta;
Can J Infect Dis. 2001 Jan;12(1):33-9. doi: 10.1155/2001/297304.
A cohort study of children with pharyngitis aged two to 16 years was conducted to assess the role of microbial and host factors in group A beta-hemolytic streptococcus (GABHS) microbiological treatment failure.
GABHS-infected children had pharyngeal swabs repeated two to five days after completing a 10-day course of penicillin V. M and T typing, and pulsed field gel electrophoresis were performed on the isolates, and the isolates were evaluated for tolerance. Patient characteristics and clinical features were noted and nasopharyngeal swabs for respiratory viruses were taken at enrolment.
Of 286 patients enrolled, 248 (87%) could be evaluated. GABHS was cultured from 104 patients (41.9%), of whom 33 (33.7%) had microbiological treatment failures on follow-up. Although there was a trend toward failure for younger children (mean 6.5+/-2.4 years versus 7.3+/-2.4 years, P=0.07) and M type 12 (24% versus 10%, P=0.08), no factors were associated with treatment failure.
开展了一项针对2至16岁咽炎患儿的队列研究，以评估微生物和宿主因素在A组β溶血性链球菌（GABHS）微生物治疗失败中的作用。
GABHS感染患儿在完成10天青霉素V疗程后2至5天重复进行咽拭子检查。对分离株进行M和T分型以及脉冲场凝胶电泳，并评估分离株的耐受性。记录患者特征和临床特征，并在入组时采集呼吸道病毒的鼻咽拭子。
在纳入的286例患者中，248例（87%）可进行评估。104例患者（41.9%）培养出GABHS，其中33例（33.7%）在随访时有微生物治疗失败情况。虽然年幼儿童（平均6.5±2.4岁对7.3±2.4岁，P=0.07）和M12型（24%对10%，P=0.08）有治疗失败的趋势，但没有因素与治疗失败相关。
