Bano G, Raina R K, Zutshi U, Bedi K L, Johri R K, Sharma S C
Department of Pharmacology and Therapeutics, Government Medical College, Jammu-Tawi, India.
Eur J Clin Pharmacol. 1991;41(6):615-7. doi: 10.1007/BF00314996.
The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline. In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance.
在一项交叉研究中，已对胡椒碱对普萘洛尔和茶碱的生物利用度及药代动力学的影响进行了研究。每组6名受试者接受单次口服剂量40毫克普萘洛尔或150毫克茶碱，单独服用或与20毫克胡椒碱联合服用，每日1次，共7天。接受胡椒碱和普萘洛尔的受试者观察到较早的达峰时间（tmax）、较高的血药浓度峰值（Cmax）和药时曲线下面积（AUC）。它使茶碱产生了更高的Cmax、更长的消除半衰期和更高的AUC。在临床实践中，口服普萘洛尔和茶碱增强的全身可用性可用于实现更好的治疗控制并提高患者依从性。
