College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
School of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Molecules. 2022 Jan 25;27(3):781. doi: 10.3390/molecules27030781.
Chronic inflammatory diseases occur in a large portion of the population and are associated with a poor diet. Key natural products found in fruits and vegetables may assist in lowering inflammation associated with chronic diseases such as obesity, diabetes, cardiovascular diseases, and cancer. This review seeks to examine the roles of several natural products, resveratrol (RES), quercetin (QUE), curcumin (CUR), piperine (PIP), epigallocatechin gallate (EGCG), and gingerol (GIN), in their ability to attenuate inflammatory markers in specific diseases states. Additionally, we will discuss findings in past and ongoing clinical trials, detail possible phytochemical-drug interactions, and provide a brief resource for researchers and healthcare professionals on natural product and supplement regulation as well as names of databases with information on efficacy, indications, and natural product-drug interactions. As diet and over-the-counter supplement use are modifiable factors and patients are interested in using complementary and alternative therapies, understanding the mechanisms by which natural products have demonstrated efficacy and the types of drugs they interact with and knowing where to find information on herbs and supplements is important for practicing healthcare providers and researchers interested in this field.
慢性炎症性疾病在很大一部分人群中发生，并与不良饮食有关。水果和蔬菜中发现的一些关键天然产物可能有助于降低与肥胖症、糖尿病、心血管疾病和癌症等慢性疾病相关的炎症。本综述旨在探讨几种天然产物（白藜芦醇（RES）、槲皮素（QUE）、姜黄素（CUR）、胡椒碱（PIP）、表没食子儿茶素没食子酸酯（EGCG）和姜辣素（GIN））在减轻特定疾病状态下炎症标志物方面的作用。此外，我们将讨论过去和正在进行的临床试验中的发现，详细介绍可能的植物化学药物相互作用，并为研究人员和医疗保健专业人员提供有关天然产物和补充剂监管以及关于功效、适应症和天然产物-药物相互作用信息的数据库名称的简要资源。由于饮食和非处方补充剂的使用是可改变的因素，并且患者有兴趣使用补充和替代疗法，因此了解天然产物已证明具有疗效的机制以及它们与哪些药物相互作用，并了解在哪里可以找到有关草药和补充剂的信息，对于对此领域感兴趣的医疗保健提供者和研究人员来说非常重要。
