Naieni Kourosh Holakouie, Ardalan Ali, Mahmoodi Mahmood, Motevalian Abbas, Yahyapoor Yoosef, Yazdizadeh Bahareh
Department of Epidemiology and Biostatistics, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
Asian Pac J Cancer Prev. 2007 Jul-Sep;8(3):395-8.
Breast cancer is the most common cancer among Iranian women. This study aimed to determine risk factors for breast cancer in the north of Iran.
A matched case-control study was conducted in Mazandaran province of Iran in 2004 of 250 biopsy proven cases of breast cancer and 500 neighbor controls that were matched by age within a 3 year period. Statistical analysis was carried out using conditional logistic regression with the backward elimination method and crude and adjusted odds ratios with related 95% CIs were estimated with Stata 8.0 software
Multivariate analysis showed that higher education (OR=4.70, 95%CI: 1.71-12.88), late menopause (OR=4.18, 95%CI: 2.54-6.88), history of induced abortion (OR=1.62, 95%CI: 1.13-2.31), positive first-degree family history of breast cancer (OR=3.14, 95%CI: 1.37-7.20), and BMI (OR=1.02, 95%CI: 1.01-1.03) were risk factors for breast cancer. Furthermore, having more episodes of full term pregnancy (OR=0.87, 95%CI: 0.80-0.95), longer duration of breast feeding (OR=0.993, 95%CI: 0.989-0.997) and parity more than 2 were shown to be protective factors.
Our study revealed the role of some modifiable determinants of breast cancer that can be focused by public health intervention in the northern community of Iran. Accordingly, the women who have one or more of the following risk factors should take the special attention to risk of breast cancer: obesity, being menopause, positive family history of breast cancer and history of induced abortion. The protective effect of longer duration of breast feeding should be encouraged too.
乳腺癌是伊朗女性中最常见的癌症。本研究旨在确定伊朗北部乳腺癌的风险因素。
2004年在伊朗马赞德兰省进行了一项配对病例对照研究，研究对象为250例经活检证实的乳腺癌病例以及500名邻居对照，这些对照在3年时间内按年龄进行配对。使用条件逻辑回归和向后剔除法进行统计分析，并使用Stata 8.0软件估计粗比值比和调整后的比值比以及相关的95%置信区间。
多变量分析表明，高等教育（比值比=4.70，95%置信区间：1.71 - 12.88）、绝经延迟（比值比=4.18，95%置信区间：2.54 - 6.88）、人工流产史（比值比=1.62，95%置信区间：1.13 - 2.31）、乳腺癌一级家族史阳性（比值比=3.14，95%置信区间：1.37 - 7.20）以及体重指数（比值比=1.02，95%置信区间：1.01 - 1.03）是乳腺癌的风险因素。此外，足月妊娠次数较多（比值比=0.87，95%置信区间：0.80 - 0.95）、母乳喂养时间较长（比值比=0.993，95%置信区间：0.989 - 0.997）以及产次超过2次被证明是保护因素。
我们的研究揭示了一些可改变的乳腺癌决定因素的作用，伊朗北部社区的公共卫生干预可聚焦于此。因此，有以下一种或多种风险因素的女性应特别关注乳腺癌风险：肥胖、绝经、乳腺癌家族史阳性以及人工流产史。同时也应鼓励延长母乳喂养时间所带来的保护作用。
