COUP-TFI协调皮质模式形成、神经发生和层状命运，并调节丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）、蛋白激酶B（AKT）和β-连环蛋白信号传导。
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.
作者信息
Faedo Andrea, Tomassy Giulio Srubek, Ruan Youlin, Teichmann Hannah, Krauss Stefan, Pleasure Samuel J, Tsai Sophia Y, Tsai Ming-Jer, Studer Michèle, Rubenstein John L R
机构信息
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA.
出版信息
Cereb Cortex. 2008 Sep;18(9):2117-31. doi: 10.1093/cercor/bhm238. Epub 2007 Dec 28.
Abstract
A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and neural differentiation, regulates the balance of early- and late-born neurons, and regulates the balanced production of different types of layer V cortical projection neurons. We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling.
摘要
皮质发育中一个主要的未解决问题是增殖、神经发生、区域生长、区域特性以及层命运特化是如何协调的。在这里，我们通过功能缺失和功能获得操作提供证据，表明COUP-TFI孤儿核受体促进腹侧皮质命运，促进细胞周期退出和神经分化，调节早出生和晚出生神经元的平衡，并调节不同类型的V层皮质投射神经元的平衡产生。我们认为，COUP-TFI通过抑制Mapk/Erk、Akt和β-连环蛋白信号传导来控制这些过程。
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