Claerhout Filip, Verbist Godelieve, Verbeken Eric, Konstantinovic Maja, De Ridder Dirk, Deprest Jan
Centre for Surgical Technologies, Faculty of Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium.
Am J Obstet Gynecol. 2008 Jan;198(1):94.e1-6. doi: 10.1016/j.ajog.2007.05.032.
The purpose of this study was to compare the long-term host response to 2 different collagen matrices versus macroporous polypropylene mesh.
Four full-thickness abdominal wall defects in 35 rabbits were reconstructed with either polypropylene (Prolene), porcine dermal (Pelvicol), or small intestine submucosal collagen matrix (SIS). Animals were sacrificed on day 30, 60, 90, 180, 365, 540, and 720 days to evaluate morphologic and biomechanical properties of explants.
Prolene provoked a fibrotic reaction within 30 days. SIS was entirely replaced by a thin fibrotic layer within 60 days. Pelvicol was encapsulated, remaining structurally unchanged up to 180 days. Thereafter, half underwent degradation by a foreign body reaction.
Prolene was integrated by an increasingly organised fibrotic scar while SIS was entirely remodelled within 60 days. Pelvicol implants underwent late onset (> or = 180 days) degradation. After 2 years of implantation there were no differences in tensiometric strength between the 3 different materials.
本研究旨在比较两种不同胶原基质与大孔聚丙烯网片的长期宿主反应。
对35只兔子的四个全层腹壁缺损分别用聚丙烯（普理灵）、猪真皮（Pelvicol）或小肠黏膜下层胶原基质（SIS）进行修复。在第30、60、90、180、365、540和720天处死动物，以评估植入物的形态学和生物力学特性。
普理灵在30天内引发纤维化反应。SIS在60天内完全被一层薄的纤维化层替代。Pelvicol被包裹，直至180天结构保持不变。此后，一半因异物反应发生降解。
普理灵被逐渐有序的纤维化瘢痕整合，而SIS在60天内完全重塑。Pelvicol植入物发生迟发性（≥180天）降解。植入2年后，三种不同材料之间的拉伸强度无差异。
