School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
Genome Biol. 2008 Jan 2;9(1):R1. doi: 10.1186/gb-2008-9-1-r1.
MetaReg http://acgt.cs.tau.ac.il/metareg/application.html is a computational tool that models cellular networks and integrates experimental results with such models. MetaReg represents established knowledge about a biological system, available today mostly in informal form in the literature, as probabilistic network models with underlying combinatorial regulatory logic. MetaReg enables contrasting predictions with measurements, model improvements and studying what-if scenarios. By summarizing prior knowledge and providing visual and computational aids, it helps the expert explore and understand her system better.
MetaReg http://acgt.cs.tau.ac.il/metareg/application.html 是一个计算工具,用于对细胞网络建模,并将实验结果与这些模型集成。MetaReg 将生物学系统的现有知识表示为概率网络模型,并具有潜在的组合调控逻辑,这些知识目前主要以文献中的非形式化形式存在。MetaReg 使对比预测与测量、模型改进和研究假设情景成为可能。通过总结先验知识并提供可视化和计算辅助,它帮助专家更好地探索和理解她的系统。