Prasad Kailash
Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
J Cardiovasc Pharmacol Ther. 2007 Dec;12(4):304-13. doi: 10.1177/1074248407307853.
Flax lignan complex (FLC) isolated from flaxseed suppresses the development of hypercholesterolemic atherosclerosis. The objectives of this study were to investigate if FLC produces regression of atherosclerosis and if regression is associated with reductions in serum lipids and oxidative stress. The studies were conducted in 4 groups of rabbits: group I, control diet (2 months); group II, 0.25% cholesterol diet (2 months); group III, 0.25% cholesterol diet (2 months) followed by regular diet (4 months); and group IV, 0.25% cholesterol diet (2 months) followed by regular diet and FLC (4 months). Serum lipids and oxidative stress parameters were measured before and at various intervals thereafter on their respective diets. The aortas were removed at the end of the protocol for assessment of atherosclerotic plaques and oxidative parameters. Atherosclerosis in group II was associated with hyperlipidemia and increased oxidative stress. Atherosclerotic changes were accelerated in group III, and this was associated with reductions in serum lipids and oxidative stress. Atherosclerotic lesions in group IV were similar to group II, but significantly smaller than those in group III, and were associated with reductions in serum lipids and oxidative stress similar to that in group III. These results indicate that FLC does not produce regression but prevents the acceleration of atherosclerosis due to the removal of cholesterol in the diet. These effects of FLC are not associated with reductions in serum lipids and oxidative stress.
从亚麻籽中分离出的亚麻木脂素复合物（FLC）可抑制高胆固醇血症性动脉粥样硬化的发展。本研究的目的是调查FLC是否能使动脉粥样硬化消退，以及消退是否与血脂和氧化应激的降低有关。研究在4组兔子中进行：第一组，给予对照饮食（2个月）；第二组，给予0.25%胆固醇饮食（2个月）；第三组，给予0.25%胆固醇饮食（2个月），随后给予常规饮食（4个月）；第四组，给予0.25%胆固醇饮食（2个月），随后给予常规饮食和FLC（4个月）。在各自饮食前及之后的不同时间间隔测量血脂和氧化应激参数。在实验方案结束时取出主动脉，用于评估动脉粥样硬化斑块和氧化参数。第二组的动脉粥样硬化与高脂血症和氧化应激增加有关。第三组的动脉粥样硬化变化加速，这与血脂和氧化应激的降低有关。第四组的动脉粥样硬化病变与第二组相似，但明显小于第三组，并且与第三组相似的血脂和氧化应激降低有关。这些结果表明，FLC不会使动脉粥样硬化消退，但由于饮食中胆固醇的去除，可防止动脉粥样硬化加速。FLC的这些作用与血脂和氧化应激的降低无关。
