Bradley Edward L, Howard Thomas J, van Sonnenberg Eric, Fotoohi Mehran
Department of Clinical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
J Gastrointest Surg. 2008 Apr;12(4):634-9. doi: 10.1007/s11605-007-0445-z. Epub 2008 Jan 3.
Interventional therapy in necrotizing pancreatitis is evolving. Efforts to modify or prevent pancreatic necrosis by intra-arterial infusion of antibiotics and antiproteases have been described. Moreover, traditional approaches to the surgical management of infected pancreatic necrosis are being challenged by a host of endoscopic and percutaneous techniques. While these approaches are potentially valuable additions to interventional therapy in necrotizing pancreatitis, few evidence-based studies are available to support their supplanting more traditional approaches at this time. Cooperative evidence-based multiinstitutional studies will be required to address the validity of these proposals.
