痛风最新进展：病理生理学与潜在治疗方法

Update on gout: pathophysiology and potential treatments.

作者信息

Abeles Aryeh M, Park Jean Y, Pillinger Michael H, Cronstein Bruce N

机构信息

Division of Rheumatology, Medical Arts and Research Building, 263 Farmington Avenue, Farmington, CT 06030, USA.

出版信息

Curr Pain Headache Rep. 2007 Dec;11(6):440-6. doi: 10.1007/s11916-007-0231-3.

DOI:10.1007/s11916-007-0231-3

PMID:18173979

Abstract

After several decades of senescence, the twin fields of hyperuricemia and gout have again regained attention in both the scientific and clinical spheres, and this review highlights several recent advancements. Specifically, we review newly discovered mechanisms of uric acid-induced inflammation, uric acid's putative role as a "danger signal" in innate immunity, the possible link between hyperuricemia and cardiovascular disease, and evolutionary evidence suggesting that hyperuricemia conferred a survival advantage in primates (when the gene for uricase was lost) several million years ago. Finally, we provide an overview of the current approach to gout, as well as what treatments are on the horizon.

摘要

经过几十年的沉寂，高尿酸血症和痛风这两个相关领域在科学和临床领域再次受到关注，本综述重点介绍了一些最新进展。具体而言，我们回顾了新发现的尿酸诱导炎症的机制、尿酸在先天免疫中作为“危险信号”的假定作用、高尿酸血症与心血管疾病之间的可能联系，以及进化证据表明几百万年前高尿酸血症在灵长类动物（当尿酸酶基因丢失时）中赋予了生存优势。最后，我们概述了目前痛风的治疗方法以及即将出现的治疗手段。