Paparini A, Rossi P, Gianfranceschi G, Brugaletta V, Falsaperla R, De Luca P, Romano Spica V
Department of Health Sciences, Public Health Unit, University Institute of Movement Sciences (IUSM), Rome, Italy.
Bioelectromagnetics. 2008 May;29(4):312-23. doi: 10.1002/bem.20399.
To analyze possible effects of microwaves on gene expression, mice were exposed to global system for mobile communication (GSM) 1800 MHz signal for 1 h at a whole body SAR of 1.1 W/kg. Gene expression was studied in the whole brain, where the average SAR was 0.2 W/kg, by expression microarrays containing over 22,600 probe sets. Comparison of data from sham and exposed animals showed no significant difference in gene expression modulation. However, when less stringent constraints were adopted to analyze microarray results, 75 genes were found to be modulated following exposure. Forty-two probes showed fold changes ranging from 1.5 to 2.8, whereas 33 were down-regulated from 0.67- to 0.29-fold changes, but these differences in gene expression were not confirmed by real-time PCR. Under these specific limited conditions, no consistent indication of gene expression modulation in whole mouse brain was found associated to GSM 1800 MHz exposure.
为分析微波对基因表达的可能影响，将小鼠置于全球移动通信系统（GSM）1800兆赫信号下，全身比吸收率为1.1瓦/千克，暴露1小时。通过包含超过22,600个探针组的表达微阵列，研究平均比吸收率为0.2瓦/千克的全脑基因表达。假手术组和暴露组动物的数据比较显示，基因表达调节无显著差异。然而，当采用不太严格的条件分析微阵列结果时，发现暴露后有75个基因被调节。42个探针显示倍数变化范围为1.5至2.8，而33个探针下调，倍数变化为0.67至0.29，但这些基因表达差异未通过实时聚合酶链反应得到证实。在这些特定的有限条件下，未发现全小鼠脑内基因表达调节与GSM 1800兆赫暴露有一致关联。
