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肺癌、乳腺癌和结直肠癌中基质金属蛋白酶的基因多态性

Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer.

作者信息

Decock J, Paridaens R, Ye S

机构信息

Laboratory for Experimental Oncology (LEO), Department of Oncology, K. U. Leuven, University Hospitals Leuven, Leuven, Belgium.

出版信息

Clin Genet. 2008 Mar;73(3):197-211. doi: 10.1111/j.1399-0004.2007.00946.x. Epub 2007 Dec 29.

DOI:10.1111/j.1399-0004.2007.00946.x
PMID:18177467
Abstract

The matrix metalloproteinases (MMPs) can degrade various components of the extracellular matrix and are implicated in the development and progression of cancer. There is evidence suggesting an association of MMP gene polymorphisms with cancer susceptibility and/or metastasis. This paper reviews the findings on several single nucleotide polymorphisms in the collagenase, stromelysin and gelatinase genes in lung cancer, breast cancer and colorectal cancer.

摘要

基质金属蛋白酶（MMPs）可降解细胞外基质的各种成分，并与癌症的发生和发展有关。有证据表明MMP基因多态性与癌症易感性和/或转移有关。本文综述了肺癌、乳腺癌和结直肠癌中胶原酶、基质溶解素和明胶酶基因的几个单核苷酸多态性的研究结果。

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