孕期和哺乳期氢化脂肪摄入会改变21日龄大鼠的血清脂质谱和脂肪因子mRNA水平。
Hydrogenated fat intake during pregnancy and lactation modifies serum lipid profile and adipokine mRNA in 21-day-old rats.
作者信息
Pisani Luciana P, Oyama Lila M, Bueno Allain A, Biz Carolina, Albuquerque Kelse T, Ribeiro Eliane B, Oller do Nascimento Claudia M
机构信息
Department of Physiology, Division of Nutrition Physiology, São Paulo Federal University-UNIFESP, São Paulo, Brazil.
出版信息
Nutrition. 2008 Mar;24(3):255-61. doi: 10.1016/j.nut.2007.12.001. Epub 2008 Jan 4.
OBJECTIVE
We examined whether feeding pregnant and lactating rats hydrogenated fats rich in trans-fatty acids modifies the plasma lipid profiles and the expression of adipokines involved with insulin resistance and cardiovascular disease in their 21-d-old offspring.
METHODS
Pregnant and lactating Wistar rats were fed with a control diet (C group) or one enriched with hydrogenated vegetable fat (T group). After delivery, male offspring were weighed weekly and killed at day 21 of life by decapitation. Blood and retroperitoneal, epididymal, and subcutaneous white adipose tissues were collected.
RESULTS
Offspring of T-group rats had increased serum triacylglycerols and cholesterol, white adipose tissue plasminogen activator inhibitor-1, and tumor necrosis factor-alpha gene expression, and carcass lipid content and decreased blood leptin and adiponectin and adiponectin gene expression.
CONCLUSION
Ingestion of hydrogenated vegetable fat by the mother during gestation and lactation alters the blood lipid profiles and the expression of proinflammatory adipokynes by the adipose tissue of offspring aged 21 d.
目的
我们研究了给怀孕和哺乳期大鼠喂食富含反式脂肪酸的氢化脂肪是否会改变其21日龄后代的血浆脂质谱以及与胰岛素抵抗和心血管疾病相关的脂肪因子的表达。
方法
将怀孕和哺乳期的Wistar大鼠喂食对照饮食（C组）或富含氢化植物油的饮食（T组）。分娩后，每周称取雄性后代体重，并在其出生第21天断头处死。收集血液以及腹膜后、附睾和皮下白色脂肪组织。
结果
T组大鼠的后代血清三酰甘油、胆固醇、白色脂肪组织纤溶酶原激活物抑制剂-1和肿瘤坏死因子-α基因表达增加，胴体脂质含量增加，而血液瘦素、脂联素及脂联素基因表达降低。
结论
母亲在妊娠和哺乳期摄入氢化植物油会改变21日龄后代的血脂谱以及脂肪组织中促炎脂肪因子的表达。
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