Moreno Gerardo, Mangione Carol M, Wang Pin-Chieh, Trejo Laura, Butch Anthony, Tseng Chi-Hong, Sarkisian Catherine A
UCLA Department of Family Medicine, 10880 Wilshire Boulevard, Suite 1800, Los Angeles, CA 90024, USA.
UCLA Department of Medicine, Division of General Internal Medicine & Health Services, 911 Broxton Avenue, Los Angeles, CA 90095, USA.
Curr Gerontol Geriatr Res. 2014;2014:535071. doi: 10.1155/2014/535071. Epub 2014 Jun 12.
Background. Physical activity is associated with better physical health, possibly by changing biological markers of health such as waist circumference and inflammation, but these relationships are unclear and even less understood among older Latinos-a group with high rates of sedentary lifestyle. Methods. Participants were 120 sedentary older Latino adults from senior centers. Community-partnered research methods were used to recruit participants. Inflammatory (C-reactive protein) and metabolic markers of health (waist circumference, HDL-cholesterol, triglycerides, insulin, and glucose), physical activity (Yale physical activity survey), and physical performance (short physical performance NIA battery) were measured at baseline and 6-month followup. Results. Eighty percent of the sample was female. In final adjusted cross-sectional models, better physical activity indices were associated with faster gait speed (P < 0.05). In adjusted longitudinal analyses, change in self-reported physical activity level correlated inversely with change in CRP (β = -0.05; P = 0.03) and change in waist circumference (β = -0.16; P = 0.02). Biological markers of health did not mediate the relationship between physical activity and physical performance. Conclusion. In this community-partnered study, higher physical activity was associated with better physical performance in cross-sectional analyses. In longitudinal analysis, increased physical activity was associated with improvements in some metabolic and inflammatory markers of health.
背景。身体活动与更好的身体健康相关，可能是通过改变健康的生物学标志物，如腰围和炎症，但这些关系尚不清楚，在久坐不动生活方式发生率较高的老年拉丁裔人群中了解得更少。方法。参与者为120名来自老年中心的久坐不动的老年拉丁裔成年人。采用社区合作研究方法招募参与者。在基线和6个月随访时测量炎症（C反应蛋白）和健康的代谢标志物（腰围、高密度脂蛋白胆固醇、甘油三酯、胰岛素和葡萄糖）、身体活动（耶鲁身体活动调查）和身体机能（简短身体机能NIA电池测试）。结果。样本中80%为女性。在最终调整的横断面模型中，更好的身体活动指数与更快的步态速度相关（P < 0.05）。在调整的纵向分析中，自我报告的身体活动水平变化与CRP变化呈负相关（β = -0.05；P = 0.03），与腰围变化呈负相关（β = -0.16；P = 0.02）。健康的生物学标志物并未介导身体活动与身体机能之间的关系。结论。在这项社区合作研究中，横断面分析显示较高的身体活动与更好的身体机能相关。在纵向分析中，身体活动增加与一些健康的代谢和炎症标志物改善相关。
