Matsuda H, Samukawa K, Kubo M
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Planta Med. 1991 Dec;57(6):523-6.
Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of acute and chronic hepatitis. Ginsenoside Ro (50 and 200 mg/kg, p.o.) inhibited the increase of serum glutamic oxaloacetic transaminase (s-GOT) and serum glutamic pyruvic transaminase (s-GPT) levels in D-galactosamine (GalN)- and carbon tetrachloride (CCl4)-induced acute hepatitic rats. Ginsenoside Ro inhibited the increase of connective tissue in the liver of CCl4-induced chronic hepatitic rats. Ginsenoside Ro showed a stronger inhibitory effect on the GalN-induced acute hepatitic model than those of the aglycone of ginsenoside Ro, oleanolic acid, or glycyrrhizic acid and its aglycone, glycyrrhetinic acid.
人参皂苷Ro是一种齐墩果烷型皂苷，已在急慢性肝炎实验模型中进行了活性筛选。人参皂苷Ro（50和200毫克/千克，口服）可抑制D-半乳糖胺（GalN）和四氯化碳（CCl4）诱导的急性肝炎大鼠血清谷草转氨酶（s-GOT）和血清谷丙转氨酶（s-GPT）水平的升高。人参皂苷Ro可抑制CCl4诱导的慢性肝炎大鼠肝脏中结缔组织的增加。人参皂苷Ro对GalN诱导的急性肝炎模型的抑制作用比人参皂苷Ro的苷元、齐墩果酸、甘草酸及其苷元甘草次酸更强。
