Mendelsohn Avi, Chalamish Yossi, Solomonovich Alexander, Dudai Yadin
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel.
Neuron. 2008 Jan 10;57(1):159-70. doi: 10.1016/j.neuron.2007.11.022.
Two groups of participants, one susceptible to posthypnotic amnesia (PHA) and the other not, viewed a movie. A week later, they underwent hypnosis in the fMRI scanner and received a suggestion to forget the movie details after hypnosis until receiving a reversal cue. The participants were tested twice for memory for the movie and for the context in which it was shown, under the posthypnotic suggestion and after its reversal, while their brain was scanned. The PHA group showed reduced memory for movie but not for context while under suggestion. Activity in occipital, temporal, and prefrontal areas differed among the groups, and, in the PHA group, between suggestion and reversal conditions. We propose that whereas some of these regions subserve retrieval of long-term episodic memory, others are involved in inhibiting retrieval, possibly already in a preretrieval monitoring stage. Similar mechanisms may also underlie other forms of functional amnesia.
两组参与者，一组易患催眠后遗忘症（PHA），另一组不易患，他们观看了一部电影。一周后，他们在功能磁共振成像扫描仪中接受催眠，并收到一条建议，即在催眠后忘记电影细节，直到收到反转提示。在催眠后暗示及其反转的情况下，对参与者进行了两次测试，以检测他们对电影及其放映背景的记忆，同时对他们的大脑进行扫描。PHA组在接受暗示时对电影的记忆减少，但对背景的记忆没有减少。枕叶、颞叶和前额叶区域的活动在两组之间存在差异，在PHA组中，暗示和反转条件之间也存在差异。我们认为，虽然这些区域中的一些区域有助于长期情景记忆的检索，但其他区域则参与抑制检索，可能已经处于检索前监测阶段。类似的机制也可能是其他形式的功能性失忆症的基础。
