Ilanne-Parikka Pirjo, Eriksson Johan G, Lindström Jaana, Peltonen Markku, Aunola Sirkka, Hämäläinen Helena, Keinänen-Kiukaanniemi Sirkka, Laakso Mauri, Valle Timo T, Lahtela Jorma, Uusitupa Matti, Tuomilehto Jaakko
Diabetes Center, Finnish Diabetes Association, Tampere, Finland.
Diabetes Care. 2008 Apr;31(4):805-7. doi: 10.2337/dc07-1117. Epub 2008 Jan 9.
The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components.
A total of 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or a standard care control group. National Cholesterol Education Program criteria were used for the definition of metabolic syndrome.
At the end of the study, with a mean follow-up of 3.9 years, we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared with the control group (odds ratio [OR] 0.62 [95% CI 0.40-0.95]) and in the prevalence of abdominal obesity (0.48 [0.28-0.81]).
The results suggest that lifestyle intervention may also reduce risk of cardiovascular disease in the long run.
本次对芬兰糖尿病预防研究的二次分析旨在评估生活方式干预对代谢综合征及其组分的影响。
总共522名糖耐量受损的中年超重男性和女性被随机分为个体化生活方式干预组或标准护理对照组。采用国家胆固醇教育计划标准来定义代谢综合征。
在研究结束时，平均随访3.9年，我们发现与对照组相比，干预组的代谢综合征患病率显著降低（优势比[OR] 0.62 [95%可信区间0.40 - 0.95]），腹部肥胖患病率也显著降低（0.48 [0.28 - 0.81]）。
结果表明，从长远来看，生活方式干预可能也会降低心血管疾病风险。
