Mustafa Amany I, Hamed Ahmed M, Kadah Ahmed S, Fawzy Eman M, El Shimi Ola S
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Cairo, Egypt.
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Indian Dermatol Online J. 2023 Jun 28;14(4):493-499. doi: 10.4103/idoj.idoj_674_22. eCollection 2023 Jul-Aug.
There is evidence to support that vitiligo is linked to metabolic syndrome (MS), confirming its systemic nature. However, the underlying pathogenic mechanisms remain unknown.
To reveal the possible association of MS with vitiligo. We also attempted to study the connection between some inflammatory markers and MS in vitiligo patients to evaluate their utility in predicting MS risk.
The study included 100 vitiligo patients with an age range between 18 to 60 years and 100 controls with matched age, gender, and body mass index. All subjects were tested for MS components. Serum visceral adipose tissue-derived serine protease inhibitor (vaspin), fatty acid binding protein 4 (FABP4), vascular adhesion protein 1 (VAP-1), chitinase-3-like protein 1 (YKL-40), and high-sensitivity C-reactive protein (hs-CRP) were also measured.
Regarding MS, it was observed in 22.0% of vitiligo patients and 2.0% of control subjects ( < 0.001). Serum FABP4, VAP-1, YKL-40, and hs-CRP concentrations were higher in patients than in the control group ( < 0.05 each), and their levels showed high sensitivity and specificity to differentiate MS when using the receiver operating characteristic (ROC). Levels of these markers, except serum vaspin, were significantly positively correlated with lipid profile markers (except high-density lipoprotein cholesterol) and fasting blood glucose levels ( < 0.05 each).
MS was more common in vitiligo patients. The levels of the biomarkers studied were significantly higher in vitiligo patients. Furthermore, their levels accurately predicted MS in vitiligo patients. According to current research, these markers may be useful in assessing MS risk in vitiligo patients. Extensive research, however, is required.
有证据支持白癜风与代谢综合征（MS）有关，证实了其全身性。然而，潜在的致病机制仍不清楚。
揭示MS与白癜风之间可能的关联。我们还试图研究白癜风患者中一些炎症标志物与MS之间的联系，以评估它们在预测MS风险方面的效用。
该研究纳入了100例年龄在18至60岁之间的白癜风患者以及100例年龄、性别和体重指数相匹配的对照组。对所有受试者进行了MS组分检测。还测量了血清内脏脂肪组织衍生的丝氨酸蛋白酶抑制剂（内脏脂肪素）、脂肪酸结合蛋白4（FABP4）、血管黏附蛋白1（VAP-1）、几丁质酶3样蛋白1（YKL-40）和高敏C反应蛋白（hs-CRP）。
关于MS，在22.0%的白癜风患者和2.0%的对照受试者中观察到（<0.001）。患者血清FABP4、VAP-1、YKL-40和hs-CRP浓度高于对照组（均<0.05），当使用受试者工作特征（ROC）曲线时，它们的水平在区分MS方面显示出高敏感性和特异性。除血清内脏脂肪素外，这些标志物的水平与脂质谱标志物（高密度脂蛋白胆固醇除外）和空腹血糖水平均呈显著正相关（均<0.05）。
MS在白癜风患者中更常见。白癜风患者中所研究的生物标志物水平显著更高。此外，它们的水平能准确预测白癜风患者的MS。根据目前的研究，这些标志物可能有助于评估白癜风患者的MS风险。然而，还需要进行广泛的研究。
