Hughes Graham R V
The London Lupus Centre, London Bridge Hospital, London SE1 7PR, United Kingdom.
Autoimmun Rev. 2008 Jan;7(3):262-6. doi: 10.1016/j.autrev.2007.11.017. Epub 2007 Dec 7.
The APS was described 25 years ago as a triad of manifestations (GRV Hughes). During the last 3 decades the disease became more systemic than systemic lupus erythematosus (SLE). The paper entails many of the old clinical findings as well as novel ones which are still not well documented in large series. The authors also refer to the second hit theory of infectious origin of APS. How to treat and indications for self monitoring the INR are detailed. The question of whether specific IVIG (directed against anti cardiolipin) or anti CD 20 be incorporated into the therapeutic armamentarium employed in APS will be answered in the near future.
抗磷脂综合征（APS）在25年前被描述为一组三联征表现（GRV·休斯）。在过去30年里，该疾病比系统性红斑狼疮（SLE）更具系统性。本文涵盖了许多既往的临床发现以及一些新发现，而这些新发现尚未在大量病例中得到充分记录。作者还提及了APS感染起源的二次打击理论。文中详细阐述了如何治疗以及国际标准化比值（INR）自我监测的指征。抗磷脂综合征治疗中是否将特定的静脉注射免疫球蛋白（针对抗心磷脂）或抗CD20纳入治疗手段的问题将在不久的将来得到解答。
