Keramat Shayan, Sharebiani Hiva, Patel Malay, Fazeli Bahare, Stanek Agata
Vascular Independent Research and Education, European Foundation, 20157 Milan, Italy.
Department of Research and Biobanking, Buerger's Disease Non-Governmental Organization, Mashhad 9183785195, Iran.
Antioxidants (Basel). 2022 Oct 28;11(11):2126. doi: 10.3390/antiox11112126.
Peripheral arterial disease (PAD) has a worldwide prevalence and is a significant cause of cardiovascular morbidity and mortality. Due to its high prevalence and higher rates of ischemic cardiovascular and lower-extremity events, its treatment is essential. Increased levels of oxidative stress cause disease. This review aimed to evaluate different studies of antioxidant treatments for PAD patients. A systematic search for relevant studies was performed on the PubMed, SCOPUS, and ScienceDirect databases, and 18 studies fulfilled the inclusion criteria. In total, 16.6% of the studies used natural antioxidants, and 83.3% used synthetic antioxidants. The reviewed studies show that natural antioxidants were completely effective in treating PAD, and synthetic antioxidants showed effective results in only 53% of the studies. A less-than-optimal pro-oxidant-antioxidant balance does not improve the symptoms of PAD. In conclusion, antioxidants in their natural forms are more effective for PAD patients, and ensuring the optimal pro-oxidant-antioxidant balance is an effective method for managing treatment with antioxidants.
外周动脉疾病（PAD）在全球范围内普遍存在，是心血管疾病发病和死亡的重要原因。由于其高患病率以及缺血性心血管和下肢事件的高发生率，其治疗至关重要。氧化应激水平升高会引发疾病。本综述旨在评估针对PAD患者的抗氧化治疗的不同研究。在PubMed、SCOPUS和ScienceDirect数据库中对相关研究进行了系统检索，18项研究符合纳入标准。总体而言，16.6%的研究使用天然抗氧化剂，83.3%的研究使用合成抗氧化剂。所综述的研究表明，天然抗氧化剂在治疗PAD方面完全有效，而合成抗氧化剂仅在53%的研究中显示出有效结果。促氧化剂 - 抗氧化剂平衡不理想并不能改善PAD症状。总之，天然形式的抗氧化剂对PAD患者更有效，确保最佳的促氧化剂 - 抗氧化剂平衡是管理抗氧化剂治疗的有效方法。
