Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes.
作者信息
Lee Dong-Youn, Yamasaki Kenshi, Rudsil Jennifer, Zouboulis Christos C, Park Geon Tae, Yang Jun-Mo, Gallo Richard L
出版信息
J Invest Dermatol. 2008 Jul;128(7):1863-6. doi: 10.1038/sj.jid.5701235. Epub 2008 Jan 17.
Abstract
摘要
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Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes.皮脂细胞表达功能性的抗菌肽，并可起到杀灭痤疮丙酸杆菌的作用。
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Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea.丝氨酸蛋白酶活性增加和cathelicidin会促进酒渣鼻的皮肤炎症。
Nat Med. 2007 Aug;13(8):975-80. doi: 10.1038/nm1616. Epub 2007 Aug 5.
2
Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes.痤疮丙酸杆菌和脂多糖可诱导人皮脂腺细胞中抗菌肽和促炎细胞因子/趋化因子的表达。
Microbes Infect. 2006 Jul;8(8):2195-205. doi: 10.1016/j.micinf.2006.04.001. Epub 2006 May 19.
3
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.一种 toll 样受体 2 反应性脂质效应途径可保护哺乳动物免受革兰氏阳性菌引起的皮肤感染。
Infect Immun. 2005 Aug;73(8):4512-21. doi: 10.1128/IAI.73.8.4512-4521.2005.
4
Cutaneous defense mechanisms by antimicrobial peptides.抗菌肽的皮肤防御机制。
J Invest Dermatol. 2005 Jul;125(1):9-13. doi: 10.1111/j.0022-202X.2004.23587.x.
5
Vitamin D induces the antimicrobial protein hCAP18 in human skin.维生素D可诱导人体皮肤产生抗菌蛋白hCAP18。
J Invest Dermatol. 2005 May;124(5):1080-2. doi: 10.1111/j.0022-202X.2005.23687.x.
6
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection.抗菌性银屑素（S100A7）可保护人类皮肤免受大肠杆菌感染。
Nat Immunol. 2005 Jan;6(1):57-64. doi: 10.1038/ni1142. Epub 2004 Nov 28.
7
Sebaceous gland in human skin--the fantastic future of a skin appendage.人类皮肤中的皮脂腺——一种皮肤附属器的奇妙未来。
J Invest Dermatol. 2003 Jun;120(6):xiv-xv. doi: 10.1046/j.1523-1747.2003.12263.x.
8
Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin.皮肤的固有防御系统——汗液中抗菌肽的表达。
J Invest Dermatol. 2002 Nov;119(5):1090-5. doi: 10.1046/j.1523-1747.2002.19507.x.
9
Endogenous antimicrobial peptides and skin infections in atopic dermatitis.特应性皮炎中的内源性抗菌肽与皮肤感染
N Engl J Med. 2002 Oct 10;347(15):1151-60. doi: 10.1056/NEJMoa021481.
10
Innate antimicrobial peptide protects the skin from invasive bacterial infection.先天性抗菌肽可保护皮肤免受侵袭性细菌感染。
Nature. 2001 Nov 22;414(6862):454-7. doi: 10.1038/35106587.
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