Lopes Agnaldo José, Capone Domenico, Mogami Roberto, Cunha Daniel Leme da, Melo Pedro Lopes de, Jansen José Manoel
Programa de Pós-graduação, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
J Bras Pneumol. 2007 Nov-Dec;33(6):671-8. doi: 10.1590/s1806-37132007000600010.
To correlate tomographic findings with pulmonary function parameters in patients with idiopathic pulmonary fibrosis (IPF).
A cross-sectional study was carried out, in which 30 nonsmoking patients with IPF were evaluated. Using a semiquantitative scoring system, the following high-resolution computerized tomography (HRCT) findings were quantified: total interstitial disease (TID), reticular abnormality/honeycombing, and ground-glass opacity (GGO). The functional variables were measured by spirometry, forced oscillation technique (FOT), helium dilution method, as well as the single-breath method of measuring diffusion capacity of the lung for carbon monoxide (DLCO).
Of the 30 patients studied, 18 were female, and 12 were male, with a mean age of 70.9 years. We found that TID and reticular abnormality and honeycombing correlated significantly (negative correlations) with the measurements of forced vital capacity (FVC), total lung capacity (TLC), DLCO, and dynamic respiratory compliance were found, as well as that GGO correlated significantly (and positively) with residual volume/TLC. The ratio of forced expiratory flow between 25 and 75% of FVC to FVC (FEF(25-75%)/FVC) correlated positively with TID, reticular abnormality/honeycombing, and GGO.
In IPF patients, the measurements of volume, diffusion, and dynamic compliance are the physiological variables which best reflect the extent of the interstitial disease on HRCT scans.
将特发性肺纤维化（IPF）患者的断层扫描结果与肺功能参数相关联。
开展一项横断面研究，评估30例不吸烟的IPF患者。使用半定量评分系统，对以下高分辨率计算机断层扫描（HRCT）结果进行量化：全间质疾病（TID）、网状异常/蜂窝状改变以及磨玻璃影（GGO）。通过肺量计、强迫振荡技术（FOT）、氦稀释法以及单次呼吸法测量肺一氧化碳弥散量（DLCO）来测量功能变量。
在研究的30例患者中，18例为女性，12例为男性，平均年龄70.9岁。我们发现TID、网状异常和蜂窝状改变与用力肺活量（FVC）、肺总量（TLC）、DLCO的测量值以及动态呼吸顺应性显著相关（负相关），并且GGO与残气量/肺总量显著正相关。FVC 25%至75%之间的用力呼气流量与FVC的比值（FEF(25 - 75%)/FVC）与TID、网状异常/蜂窝状改变和GGO呈正相关。
在IPF患者中，容积、弥散和动态顺应性的测量是最能反映HRCT扫描中间质疾病程度的生理变量。
