Martín-Sáez E, Fernández-Guarino M, Carrillo-Gijón R, Muñoz-Zato E, Jaén-Olasolo P
Servicio de Dermatología. Hospital Universitario Ramón y Cajal. Madrid. España.
Actas Dermosifiliogr. 2008 Jan-Feb;99(1):64-8.
Granuloma annulare is a dermatosis of unknown cause that is generally self-limiting and has several clinical forms of presentation. It may be associated with pruritus or present asymptomatically. The disseminated variant of the disease accounts for 15 % of all cases. Most authors consider that the duration of this form is longer and that treatment response is worse than for localized forms. A range of therapeutic options have been tried for this disease with a wide range of outcomes. We present a patient with disseminated granuloma annulare who started treatment with dapsone after several therapeutic failures. With dapsone therapy, her cutaneous symptoms showed a clear improvement without any relevant side effects. We then review reports in the literature of cases of disseminated granuloma annulare treated with dapsone.
环状肉芽肿是一种病因不明的皮肤病，通常具有自限性，有多种临床呈现形式。它可能伴有瘙痒，也可能无症状。该疾病的播散型占所有病例的15%。大多数作者认为，这种类型的病程较长，且治疗反应比局限性类型更差。针对这种疾病已经尝试了一系列治疗选择，结果差异很大。我们报告一例播散性环状肉芽肿患者，在经历多次治疗失败后开始使用氨苯砜治疗。使用氨苯砜治疗后，她的皮肤症状明显改善，且无任何相关副作用。然后我们回顾了文献中关于用氨苯砜治疗播散性环状肉芽肿病例的报告。
