Nedelkov Dobrin
Institute for Population Proteomics, and Intrinsic Bioprobes, Inc., Tempe, AZ 85284, USA.
Proteomics. 2008 Feb;8(4):779-86. doi: 10.1002/pmic.200700501.
Outlined in this review is the concept of population proteomics, its aspects, enabling approaches, and significance in understanding proteins' roles in physiological processes and diseases. Population proteomics addresses the need for individual assessment of proteins across large populations to delineate the existence of structural variations, determine their frequency, and explore the association of the modifications with specific diseases. Besides the basic concepts and underlying reasons for such protein diversity studies, also reviewed here are the results of two fundamental studies that investigated human plasma protein diversity across the healthy population in the United States. Such studies of protein diversity are needed to map all the post-expression protein modifications and determine the wild-type protein profiles, similar to the human diversity studies at the genome level that have helped redefine the "normal" human genome.
本综述概述了群体蛋白质组学的概念、其各个方面、实现方法以及在理解蛋白质在生理过程和疾病中的作用方面的意义。群体蛋白质组学满足了对大量人群中的蛋白质进行个体评估的需求，以描绘结构变异的存在、确定其频率，并探索这些修饰与特定疾病的关联。除了此类蛋白质多样性研究的基本概念和根本原因外，本文还综述了两项基础研究的结果，这两项研究调查了美国健康人群的血浆蛋白质多样性。需要进行此类蛋白质多样性研究来绘制所有表达后蛋白质修饰图谱并确定野生型蛋白质谱，类似于在基因组水平上进行的人类多样性研究，后者有助于重新定义“正常”人类基因组。
