Lee June Hyunkyung, Kim Seong Eon, Lee Ai-Young
Department of Dermatology, Eulji Medical Center, College of Medicine, Eulji University, Seoul, and Department of Dermatology, Dongguk University School of Medicine, Kyenggi-do, South Korea.
Int J Dermatol. 2008 Feb;47(2):183-6. doi: 10.1111/j.1365-4632.2008.03426.x.
Triamcinolone acetonide intralesional injection (TAIL) has been used for the treatment of keloids, but only with limited success. Interferon-alpha (IFN-alpha) is the most widely used IFN, and has mainly antiviral, antiproliferative, and antitumoral functions. A few studies have evaluated the efficacy of IFN-alpha2b in controlled trials for the treatment of keloids.
To compare the efficacy and side-effects of keloid treatment using IFN-alpha2b and TAIL, and TAIL only.
Twenty lesions (combined TAIL + IFN-alpha2b group) and 20 control lesions (TAIL-only group) were studied in 19 patients (14 women and five men). The age range was 7-51 years (mean age, 24.6 years). Both groups were treated with TAIL every 2 weeks. The combined TAIL + IFN-alpha2b group was treated with intralesional injection of IFN-alpha2b, twice a week. Lesion measurements were made using thread, glue, and alginate.
Statistically significant decreases in depth (81.6%, P = 0.005) and volume (86.6%, P = 0.002) were observed in lesions of the combined TAIL + IFN-alpha2b group. In the TAIL-only group, the decreases in depth (66.0%, P = 0.281) and volume (73.4%, P = 0.245) were less statistically significant. The main side-effects were fever and flu-like symptoms, mild pain, and inflammation at the injection site.
Intralesional IFN-alpha2b is an effective and safe treatment for keloids. Although the recurrence rate is as yet unknown, more than 80% improvement was noted in the majority of cases. Hence, adjuvant intralesional IFN-alpha2b should be considered, particularly for patients who have a history of failed corticosteroid injections.
曲安奈德皮损内注射（TAIL）已用于瘢痕疙瘩的治疗，但效果有限。α-干扰素（IFN-α）是应用最广泛的干扰素，主要具有抗病毒、抗增殖和抗肿瘤功能。一些研究评估了α-干扰素2b在瘢痕疙瘩治疗对照试验中的疗效。
比较使用α-干扰素2b联合TAIL与单纯TAIL治疗瘢痕疙瘩的疗效和副作用。
对19例患者（14例女性和5例男性）的20个皮损（TAIL+α-干扰素2b联合组）和20个对照皮损（单纯TAIL组）进行研究。年龄范围为7至51岁（平均年龄24.6岁）。两组均每2周接受一次TAIL治疗。TAIL+α-干扰素2b联合组每周两次皮损内注射α-干扰素2b。使用线、胶水和藻酸盐对皮损进行测量。
TAIL+α-干扰素2b联合组皮损的深度（81.6%，P=0.005）和体积（86.6%，P=0.002）在统计学上有显著下降。在单纯TAIL组中，深度（66.0%，P=0.281）和体积（73.4%，P=0.245）的下降在统计学上不那么显著。主要副作用为发热和流感样症状、轻度疼痛以及注射部位炎症。
皮损内注射α-干扰素2b是治疗瘢痕疙瘩的一种有效且安全的方法。虽然复发率尚不清楚，但大多数病例有超过80%的改善。因此，应考虑辅助皮损内注射α-干扰素2b，特别是对于有皮质类固醇注射失败史的患者。
