Meizoso T, Rivera T, Fernández-Aceñero M J, Mestre M J, Garrido M, Garaulet C
Department of Surgical Pathology, Hospital General of Móstoles, C/ Río Júcar s/n, 28935 Móstoles, Madrid, Spain.
Arch Gynecol Obstet. 2008 Aug;278(2):173-6. doi: 10.1007/s00404-007-0554-7. Epub 2008 Jan 24.
Despite the high incidence of candida vaginitis, intraamniotic candida infection seems to be a rare disease. This infective agent can cause chorioamnionitis even in the presence of intact fetal membranes.
We report four new cases of intrauterine candidiasis and describe the associated clinicopathological features. Three of the cases had predisposing risk factors, like rupture of membranes or intrauterine contraceptive device, and ended in fetal death; the fourth case had a gestational trophoblastic disease.
The pathogenic significance of fetal contamination by candida appears to depend largely on gestational age. Candida infection of the fetus can result in prematurity and death. The importance of early and accurate diagnosis of intraamniotic infection with candida is emphasized.
尽管念珠菌性阴道炎发病率很高，但羊膜腔内念珠菌感染似乎是一种罕见疾病。即使胎膜完整，这种感染源也可引起绒毛膜羊膜炎。
我们报告了4例新的宫内念珠菌病病例，并描述了相关的临床病理特征。其中3例有胎膜破裂或宫内节育器等易感危险因素，均以胎儿死亡告终；第4例患有妊娠滋养细胞疾病。
念珠菌感染胎儿的致病意义似乎很大程度上取决于孕周。胎儿念珠菌感染可导致早产和死亡。强调了早期准确诊断羊膜腔内念珠菌感染的重要性。
