Moghissi Keyvan, Dixon Kate
The Yorkshire Laser Centre, Goole & District Hospital, Woodland Avenue, Goole, East Yorkshire, DN14 6RX, UK.
Lasers Med Sci. 2009 Mar;24(2):252-8. doi: 10.1007/s10103-007-0538-7. Epub 2008 Jan 23.
Eighty patients amongst 850 undergoing pulmonary surgery with the use of neodymium:yttrium-aluminium-garnet (Nd:YAG) laser had a solitary pulmonary nodule (< or = 50 mm) on chest radiography, which was confirmed or suspected pre-operatively to be primary lung cancer. All patients had a mini-thoracotomy to expose the lesion. They then had Nd:YAG laser to excise the nodule locally. There was no hospital mortality. Six patients had non-fatal post-operative complications. Pathologically, 46 patients had primary lung cancer and ten had secondary lung cancer. Twenty-four others had benign lesions. Mean hospital stay was 5.5 days. Post-operative reduction of forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)) was 14% and 13% (mean), respectively. Thirty-seven patients with primary lung cancer were followed up for between 12 months and 60 months. Mean survival time of these patients was 39 months (s.d. 13 months). It was concluded that Nd:YAG laser for pulmonary nodular lesions should be considered for a selected group of patients unsuitable for standard resection.
850例接受钕钇铝石榴石(Nd:YAG)激光肺手术的患者中,有80例在胸部X线片上有孤立性肺结节(≤50mm),术前经确认或怀疑为原发性肺癌。所有患者均接受了小切口开胸手术以暴露病变。然后使用Nd:YAG激光在局部切除结节。无医院死亡病例。6例患者出现非致命性术后并发症。病理检查显示,46例为原发性肺癌,10例为继发性肺癌,另外24例为良性病变。平均住院时间为5.5天。术后第一秒用力肺活量(FVC)和第一秒用力呼气量(FEV₁)平均分别下降了14%和13%。37例原发性肺癌患者接受了12个月至60个月的随访。这些患者的平均生存时间为39个月(标准差13个月)。结论是,对于选定的不适合标准切除术的患者群体,应考虑使用Nd:YAG激光治疗肺结节性病变。