棕榈酸视黄醇滴眼液对正庚醇诱导的兔角膜结膜上皮损伤的影响。
Effect of retinol palmitate eye drops on experimental keratoconjunctival epithelial damage induced by n-heptanol in rabbit.
作者信息
Toshida Hiroshi, Odaka Akito, Koike Daisuke, Murakami Akira
机构信息
Department of Ophthalmology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
出版信息
Curr Eye Res. 2008 Jan;33(1):13-8. doi: 10.1080/02713680701827696.
PURPOSE
To investigate ability of vitamin A (VA, retinol palmitate) to promote wound healing after injury in rabbit eye.
METHODS
After keratoconjunctival injury by 20 microL of n-heptanol, VA eye drops at 500, 1000, or 1500 IU/mL were started 6 times a day for 11 days. Fluorescein and rose bengal staining and histological analysis were performed.
RESULTS
Fluorescein staining was significantly reduced by 1000 and 1500 IU/mL of VA and rose bengal staining by all concentrations. Histological examination revealed acceleration of wound healing after 7 days (1500 IU/mL).
CONCLUSIONS
VA may be useful in treatment of keratoconjunctival injury.
目的
研究维生素A（VA，视黄醇棕榈酸酯）促进兔眼损伤后伤口愈合的能力。
方法
用20微升正庚醇造成角结膜损伤后，开始每天6次滴入浓度为500、1000或1500国际单位/毫升的VA眼药水，持续11天。进行荧光素和孟加拉玫瑰红染色以及组织学分析。
结果
1000和1500国际单位/毫升的VA显著减少了荧光素染色，所有浓度的VA均减少了孟加拉玫瑰红染色。组织学检查显示7天后（1500国际单位/毫升）伤口愈合加速。
结论
VA可能对角结膜损伤的治疗有用。
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