孔源性视网膜脱离患者眼内视网膜下液和玻璃体中可溶性syndecan-1水平升高。

Increased levels of soluble syndecan-1 in the subretinal fluid and the vitreous of eyes with rhegmatogenous retinal detachment.

作者信息

Wang Jing-Bo, Tian Chao-Wei, Guo Chang-Mei, Du Hong-Jun, Liu Hong-Lei, Zhang Yan-Jun, Hui Yan-Nian

机构信息

Department of Ophthalmology, Xijing Hospital, Xi'an, Shaanxi, China.

出版信息

Curr Eye Res. 2008 Jan;33(1):101-7. doi: 10.1080/02713680701809272.

DOI:10.1080/02713680701809272

PMID:18214747

Abstract

PURPOSE

To investigate whether rhegmatogenous retinal detachment (RRD) alters intraocular soluble syndecan-1 levels.

METHODS

In all, 39 samples of subretinal fluid (SRF) and 10 samples of vitreous fluid from RRD patients were collected. Using ELISA, soluble syndecan-1 levels were detected, and potential correlations between syndecan-1 levels with clinical parameters were analyzed.

RESULTS

Soluble syndecan-1 in the vitreous fluid (2.577+/-0.578 ng/ml) and in the SRF (1.499+/-0.184 ng/ml) from eyes with RRD enhanced significantly compared to that of the controls (0.224+/-0.095 ng/ml) (p<0.0001 and p=0.006). An increase in the syndecan-1 concentrations in SRF samples correlated with a longer duration of retinal detachment (r=0.716, p<0.0001) and a younger age (r= -0.341, p=0.017).

CONCLUSIONS

RRD was found to be associated with a significant increase of soluble syndecan-1 in the vitreous fluid and SRF. In SRF, an enhanced soluble syndecan-1 concentration correlated positively with the duration of retinal detachment and inversely with the age of patients.

摘要

目的

研究孔源性视网膜脱离（RRD）是否会改变眼内可溶性syndecan-1水平。

方法

共收集了39例RRD患者的视网膜下液（SRF）样本和10例玻璃体液样本。采用酶联免疫吸附测定法（ELISA）检测可溶性syndecan-1水平，并分析syndecan-1水平与临床参数之间的潜在相关性。

结果

与对照组（0.224±0.095 ng/ml）相比，RRD患者眼内玻璃体液（2.577±0.578 ng/ml）和SRF（1.499±0.184 ng/ml）中的可溶性syndecan-1显著升高（p<0.0001和p=0.006）。SRF样本中syndecan-1浓度的增加与视网膜脱离时间延长相关（r=0.716，p<0.0001），与年龄较小相关（r=-0.341，p=0.017）。