Faculty of Medicine, University of Toronto, Toronto, ON.
Curr Oncol. 2012 Aug;19(4):e299-302. doi: 10.3747/co.19.997.
Paraneoplastic acanthosis nigricans (pan) is an infrequently encountered cutaneous manifestation of internal malignancy. Here, we describe a case of pan in the setting of a known breast ductal carcinoma in situ, which, to our knowledge, had not been described in association with pan. As a result, thorough investigation was undertaken to search for another concurrent neoplasm that would better explain the development of pan. In so doing, we identified a coexisting metastatic cholangiocarcinoma. We thus conclude that when pan is observed in an uncommon association with a known malignancy, further investigation should be undertaken to explore whether a more likely occult culprit exists.
副肿瘤性黑棘皮病（pan）是一种罕见的皮肤表现，与内部恶性肿瘤有关。在这里，我们描述了一例已知乳腺导管原位癌伴 pan 的病例，据我们所知，尚未有与 pan 相关的病例描述。因此，我们进行了彻底的调查，以寻找另一种同时存在的肿瘤，以便更好地解释 pan 的发生。结果，我们发现了同时存在的转移性胆管癌。因此，我们得出结论，当 pan 与已知恶性肿瘤罕见地同时存在时，应进行进一步调查，以探讨是否存在更可能的隐匿性罪魁祸首。
