Pamuk Gülsüm Emel, Harmandar Ferda, Ermantaş Nilay, Harmandar Orbay, Turgut Burhan, Demir Muzaffer, Vural Ozden
Division of Hematology, Trakya University Medical Faculty, Edirne, Turkey.
Ann Hematol. 2008 Apr;87(4):305-10. doi: 10.1007/s00277-008-0445-4. Epub 2008 Jan 25.
We aimed to evaluate the prevalences of self-reported anxiety and depression symptoms in hematological malignancy patients and to determine the association between the presence of these disorders and the results of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-30 (EORTC QLQ-C30). One hundred and forty patients with a diagnosis of a hematological malignancy completed the Hospital Anxiety and Depression Scale (HADS) and the General Health Questionnaire. Patients with higher anxiety scores were more frequently inpatients, had higher EORTC general symptom scores, and they had lower cognitive, emotional, social functioning and global quality of life (QoL) scores (all p values <0.05). Patients with higher depression scores had more frequently active disease and were inpatients; they had higher mean Eastern Cooperative Oncology Group performance scores, EORTC gastrointestinal system and general symptom scores, and significantly lower physical, role, emotional, social and cognitive functioning and global QoL scores (all p values <0.01). During follow-up, it was observed that survival curves of patients with active disease who had higher HADS depression scores tended to be shorter than those with lower scores (p = 0.1). Anxiety and depression are frequent in hematological malignancy patients and associated with poor QoL and performance status. In addition, the presence of self-reported depression might have a predictive value for poor prognosis.
我们旨在评估血液系统恶性肿瘤患者自我报告的焦虑和抑郁症状的患病率，并确定这些疾病的存在与欧洲癌症研究与治疗组织生活质量问卷-30（EORTC QLQ-C30）结果之间的关联。140例诊断为血液系统恶性肿瘤的患者完成了医院焦虑抑郁量表（HADS）和一般健康问卷。焦虑评分较高的患者更常为住院患者，EORTC总体症状评分较高，而认知、情感、社会功能和总体生活质量（QoL）评分较低（所有p值<0.05）。抑郁评分较高的患者疾病活动更频繁且为住院患者；他们的东部肿瘤协作组平均表现评分、EORTC胃肠道系统和总体症状评分较高，而身体、角色、情感、社会和认知功能以及总体QoL评分显著较低（所有p值<0.01）。在随访期间，观察到HADS抑郁评分较高的疾病活动患者的生存曲线往往比评分较低的患者短（p = 0.1）。焦虑和抑郁在血液系统恶性肿瘤患者中很常见，且与生活质量差和表现状态有关。此外，自我报告的抑郁状态可能对预后不良具有预测价值。
