Santos Fábio R M, Kozasa Elisa H, Chauffaille Maria de Lourdes L F, Colleoni Gisele W B, Leite Jose Roberto
Psychobiology Department, Universidade Federal de São Paulo, Rua Napoleão de Barros No. 925, São Paulo, Brazil.
J Psychosom Res. 2006 May;60(5):505-11. doi: 10.1016/j.jpsychores.2005.08.017.
This study aims to investigate the prevalence of posttraumatic stress disorder (PTSD) symptoms, anxiety, and depression in patients with hematological malignancies, and to investigate the possible relationship between these symptoms and variables such as demographic data, social support, and quality of life (QOL). We studied 107 patients: 54 with non-Hodgkin's lymphoma (NHL), 18 acute myelogenous leukaemia (AML), 10 acute lymphoblastic leukaemia (ALL), and 25 multiple myeloma (MM). Demographic data were collected, and three standardized instruments were applied to this group of patients: Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire of QOL. The results showed a significant percentage of patients presenting with symptoms: 13% had high levels of intrusive thoughts, 20.5% had high levels of anxiety, and 16.8% had high levels of depression. Patients with MM had the lowest QOL scores in the EORTC physical functioning subscale. Patients under intravenous chemotherapy treatment had a higher level of anxiety than the monitoring patients. Patients with recent diagnosis had a level of intrusion symptoms (IES) relevantly higher than the others. The unemployed patients and those with lower social support had levels of stress, anxiety, and depression significantly higher than the others. Our results confirm the high incidence of intrusion, avoidance, anxiety, and depression in patients with hematological malignancies and highlight the importance of a multidisciplinary staff to complement the treatment of these patients, including psychosocial assistance.
本研究旨在调查血液系统恶性肿瘤患者创伤后应激障碍（PTSD）症状、焦虑和抑郁的患病率，并研究这些症状与人口统计学数据、社会支持和生活质量（QOL）等变量之间的可能关系。我们研究了107例患者：54例非霍奇金淋巴瘤（NHL）、18例急性髓性白血病（AML）、10例急性淋巴细胞白血病（ALL）和25例多发性骨髓瘤（MM）。收集了人口统计学数据，并对这组患者应用了三种标准化工具：医院焦虑抑郁量表（HADS）、事件影响量表（IES）、欧洲癌症研究与治疗组织（EORTC）生活质量QLQ-C30问卷。结果显示，出现症状的患者比例显著：13%有高水平的侵入性思维，20.5%有高水平的焦虑，16.8%有高水平的抑郁。在EORTC身体功能子量表中，MM患者的生活质量得分最低。接受静脉化疗的患者比接受监测的患者焦虑水平更高。近期诊断的患者侵入症状（IES）水平明显高于其他患者。失业患者和社会支持较低的患者的压力、焦虑和抑郁水平明显高于其他患者。我们的结果证实了血液系统恶性肿瘤患者中侵入、回避、焦虑和抑郁的高发生率，并强调了多学科工作人员对补充这些患者治疗的重要性，包括心理社会援助。
