干细胞治疗：磁共振成像引导与监测
Stem cell therapy: MRI guidance and monitoring.
作者信息
Kraitchman Dara L, Gilson Wesley D, Lorenz Christine H
机构信息
Johns Hopkins University, School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD 21287, USA.
出版信息
J Magn Reson Imaging. 2008 Feb;27(2):299-310. doi: 10.1002/jmri.21263.
Abstract
With the recent advances in magnetic resonance (MR) labeling of cellular therapeutics, it is natural that interventional MRI techniques for targeting would be developed. This review provides an overview of the current methods of stem cell labeling and the challenges that are created with respect to interventional MRI administration. In particular, stem cell therapies will require specialized, MR-compatible devices as well as integration of graphical user interfaces with pulse sequences designed for interactive, real-time delivery in many organs. Specific applications that are being developed will be reviewed as well as strategies for future translation to the clinical realm.
摘要
随着细胞治疗磁共振（MR）标记技术的最新进展，开发用于靶向的介入性MRI技术是自然而然的。本综述概述了当前干细胞标记方法以及介入性MRI给药方面所面临的挑战。特别是，干细胞治疗将需要专门的、与MR兼容的设备，以及将图形用户界面与为许多器官的交互式实时输送而设计的脉冲序列相结合。正在开发的具体应用以及未来向临床领域转化的策略也将进行综述。
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