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注意缺陷多动障碍不同亚型儿童低频振幅和功能连接的异常：一项静息态功能近红外光谱研究

Aberrant amplitude of low-frequency fluctuation and functional connectivity in children with different subtypes of ADHD: a resting-state fNIRS study.

作者信息

Liu Qinwei, Liao Wenjing, Yang Li, Cao Longfei, Liu Ningning, Gu Yongxue, Wang Shaohua, Xu Xiaobin, Wang Huafen

机构信息

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

出版信息

BMC Psychiatry. 2024 Dec 18;24(1):919. doi: 10.1186/s12888-024-06350-6.

DOI:10.1186/s12888-024-06350-6
PMID:39696119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11658069/
Abstract

BACKGROUND

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with different subtypes of pathogenesis. Insufficient research on the subtypes of ADHD has limited the effectiveness of therapeutic methods.

METHODS

This study used resting-state functional near-infrared spectroscopy (fNIRS) to record hemodynamic signals in 34 children with ADHD-combined subtype (ADHD-C), 52 children with ADHD-inattentive subtype (ADHD-I), and 24 healthy controls (HCs). The amplitude of low-frequency fluctuation (ALFF) and the functional connectivity (FC) analysis were conducted for all subjects.

RESULTS

Compared with HCs, the ADHD group exhibited significantly increased ALFF and decreased FC. The ADHD-C group showed significantly higher ALFF in partial brain regions and significantly lower FC between multiple brain regions than participants with ADHD-I. The male group displayed a significant increase in ALFF in some brain regions, while no significant difference was found in FC when compared to the female group.

CONCLUSIONS

This study provides evidence to support the subtype classification of ADHD-I and ADHD-C, and the combined analysis of ALFF and FC has the potential to be a promising biomarker for the diagnosis of ADHD.

摘要

背景

注意力缺陷多动障碍（ADHD）是一种具有不同发病机制亚型的神经发育障碍。对ADHD亚型的研究不足限制了治疗方法的有效性。

方法

本研究采用静息态功能近红外光谱（fNIRS）记录34名注意缺陷多动障碍合并型（ADHD-C）儿童、52名注意缺陷多动障碍注意力不集中型（ADHD-I）儿童和24名健康对照（HCs）的血流动力学信号。对所有受试者进行低频振幅（ALFF）和功能连接（FC）分析。

结果

与健康对照组相比，ADHD组的ALFF显著增加，FC降低。与ADHD-I组相比，ADHD-C组在部分脑区的ALFF显著更高，多个脑区之间的FC显著更低。男性组在某些脑区的ALFF显著增加，而与女性组相比，FC未发现显著差异。

结论

本研究为支持ADHD-I和ADHD-C的亚型分类提供了证据，ALFF和FC的联合分析有可能成为ADHD诊断的有前景的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/ab9893ba012b/12888_2024_6350_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/8f437c855c7f/12888_2024_6350_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/4a90c9a7ba50/12888_2024_6350_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/ffb5b8e76a97/12888_2024_6350_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/cbcd702e16cc/12888_2024_6350_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/5eaf56bdb1b6/12888_2024_6350_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/ab9893ba012b/12888_2024_6350_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/8f437c855c7f/12888_2024_6350_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/4a90c9a7ba50/12888_2024_6350_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/ffb5b8e76a97/12888_2024_6350_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/cbcd702e16cc/12888_2024_6350_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/5eaf56bdb1b6/12888_2024_6350_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed3/11658069/ab9893ba012b/12888_2024_6350_Fig6_HTML.jpg

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