Koifman S, Pombo-de-Oliveira M S
National School of Public Health/FIOCRUZ, Rua Leopoldo Bulhões, 1480, Rio de Janeiro, RJ 21041-210, Brazil.
Br J Cancer. 2008 Feb 12;98(3):664-7. doi: 10.1038/sj.bjc.6604202. Epub 2008 Jan 29.
In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999-2005. Compared with the general population and the stratum 2500-2999 g as reference, IL cases weighing 3000-3999 g presented an odds ratio (OR) of 1.68 (95% CI: 1.03-2.76), and those of 4000 g or more, an OR of 2.28 (95% CI: 1.08-4.75), P trend<0.01. Using hospital-based controls, the OR for 4000 g or more, compared to 2500-2999 g, was 1.30 (95% CI: 1.02-1.43) after adjusting for confounders (gender, income, maternal age, pesticide and hormonal exposure during pregnancy). The results suggest that high birth weight is associated with increased risk of IL.
在本文中，我们比较了201例婴儿白血病（IL）病例与1999年至2005年在巴西登记的440例非癌症对照者的出生体重分布情况。与一般人群以及以2500 - 2999克这一层为参照相比，体重在3000 - 3999克的IL病例的优势比（OR）为1.68（95%置信区间：1.03 - 2.76），体重在4000克及以上的病例，优势比为2.28（95%置信区间：1.08 - 4.75），P趋势<0.01。使用基于医院的对照，在对混杂因素（性别、收入、母亲年龄、孕期农药和激素暴露）进行调整后，与2500 - 2999克相比，4000克及以上的OR为1.30（95%置信区间：1.02 - 1.43）。结果表明，高出生体重与IL风险增加有关。
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