Walker V, Pickard J D, Smythe P J, Perry S
University Department of Clinical Biochemistry, Southampton General Hospital, UK.
J Neurooncol. 1991 Dec;11(3):259-62. doi: 10.1007/BF00165535.
Brain tumours produce prostaglandins in vitro; their in vivo production has been studied by determining the levels of prostaglandin F2 alpha, prostaglandin E2, 6-ketoprostaglandin F1 alpha and thromboxane B2 in tumour cyst fluid and ventricular CSF taken from 21 patients with a variety of intracranial tumours. The levels were high in tumour cyst fluid but there was no overall increase in ventricular CSF. Hence, brain tumours do not produce a consistent pattern of abnormality of eicosanoid concentrations in the ventricular CSF that would be useful for diagnosis. If brain tumours produce excess quantities of these prostaglandins in vivo as they do in vitro, these prostaglandins may be rapidly cleared by the cerebral microvasculature unless compartmentalized within a tumour cyst.
脑肿瘤在体外可产生前列腺素；通过测定21例患有各种颅内肿瘤患者的肿瘤囊液和脑室脑脊液中前列腺素F2α、前列腺素E2、6-酮前列腺素F1α和血栓素B2的水平，对其体内生成情况进行了研究。肿瘤囊液中的水平较高，但脑室脑脊液中总体上没有升高。因此，脑肿瘤不会在脑室脑脊液中产生一致的类花生酸浓度异常模式，而这种模式对诊断并无帮助。如果脑肿瘤在体内像在体外一样产生过量的这些前列腺素，除非在肿瘤囊肿内被分隔，否则这些前列腺素可能会被脑微血管迅速清除。
