Pickard J D, Walker V, Newton H, Smythe P J, Perry S
University Departments of Clinical Neurological Sciences, Southampton, England.
Neurosurgery. 1990 Dec;27(6):943-5. doi: 10.1097/00006123-199012000-00013.
The concentrations of prostaglandin F2 alpha, prostaglandin E2, 6-ketoprostaglandin F1 alpha (prostacyclin metabolite), and thromboxane B2 were assayed in ventricular cerebrospinal fluid obtained from 28 patients with hydrocephalus (17 obstructive, 11 communicating). Seven patients received dexamethasone or hydrocortisone on the day of sampling. No patient received nonsteroidal anti-inflammatory compounds for 48 hours before sampling. The median values did not differ significantly between the two types of hydrocephalus or from the concentrations in lumbar cerebrospinal fluid obtained from patients without intracranial pathology during lumbar myelography for possible lumbar disc disease. Hence, there is no evidence that eicosanoids accumulate in the ventricles in hydrocephalus, and it is unlikely that they have a significant role in its symptomatology.
对从28例脑积水患者（17例梗阻性脑积水，11例交通性脑积水）获取的脑室脑脊液中的前列腺素F2α、前列腺素E2、6-酮前列腺素F1α（前列环素代谢物）和血栓素B2浓度进行了测定。7例患者在采样当天接受了地塞米松或氢化可的松治疗。在采样前48小时内，没有患者使用非甾体类抗炎化合物。两种类型的脑积水之间的中位数与在腰椎脊髓造影检查可能的腰椎间盘疾病时从无颅内病变的患者获取的腰段脑脊液中的浓度相比，差异无统计学意义。因此，没有证据表明类花生酸在脑积水患者的脑室中蓄积，并且它们在其症状学中不太可能起重要作用。
