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一项关于乳制品消费与代谢风险因素变化关系的前瞻性研究:霍恩研究。

A prospective study of dairy consumption in relation to changes in metabolic risk factors: the Hoorn Study.

作者信息

Snijder Marieke B, van Dam Rob M, Stehouwer Coen D A, Hiddink Gerrit J, Heine Robert J, Dekker Jacqueline M

机构信息

Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

出版信息

Obesity (Silver Spring). 2008 Mar;16(3):706-9. doi: 10.1038/oby.2007.93. Epub 2008 Jan 17.

Abstract

OBJECTIVE

Higher dairy consumption has been suggested to reduce the risk of obesity and metabolic disturbances. The aim of our study was to investigate the prospective association between dairy consumption and changes in weight and metabolic disturbances.

METHODS AND PROCEDURES

Baseline dairy intake (servings/day) was assessed by a semi-quantitative food-frequency questionnaire in 1,124 participants of the Hoorn Study. Linear and logistic regression analyses were performed to investigate the association between dairy intake and 6.4-year change in weight, fat distribution, and metabolic risk factors (glucoses, lipids, blood pressure) and the incidence of metabolic syndrome (MS).

RESULTS

Baseline dairy consumption was not associated with changes in fasting and post-load glucose concentrations, serum lipid levels (high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides), or blood pressure, nor with the risk of developing the MS in 6.4 years (odds ratio with 95% confidence interval was 0.86 (0.52-1.42) comparing highest with lowest quartile of dairy consumption). In subjects with BMI < 25 kg/m(2), higher dairy consumption was significantly associated with an increase in BMI, weight, waist, and a decrease in high-density lipoprotein.

DISCUSSION

Our results do not support the hypothesis that a higher dairy consumption protects against weight gain and development of metabolic disturbances in a Dutch elderly population.

摘要

目的

有人提出增加乳制品摄入量可降低肥胖和代谢紊乱的风险。我们研究的目的是调查乳制品摄入量与体重变化及代谢紊乱之间的前瞻性关联。

方法与步骤

通过半定量食物频率问卷对霍伦研究中的1124名参与者的基线乳制品摄入量(份/天)进行评估。进行线性和逻辑回归分析,以研究乳制品摄入量与6.4年体重变化、脂肪分布、代谢风险因素(血糖、血脂、血压)以及代谢综合征(MS)发病率之间的关联。

结果

基线乳制品摄入量与空腹和餐后血糖浓度、血脂水平(高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯)或血压的变化无关,也与6.4年内发生MS的风险无关(将乳制品摄入量最高四分位数与最低四分位数相比,优势比及其95%置信区间为0.86(0.52 - 1.42))。在体重指数(BMI)<25 kg/m²的受试者中,较高的乳制品摄入量与BMI、体重、腰围增加以及高密度脂蛋白降低显著相关。

讨论

我们的结果不支持以下假设,即较高的乳制品摄入量可防止荷兰老年人群体重增加和发生代谢紊乱。

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