Buyken Anette E, Karaolis-Danckert Nadina, Remer Thomas, Bolzenius Katja, Landsberg Beate, Kroke Anja
Research Institute of Child Nutrition, Department of Nutrition and Health, Rheinische Friedrich-Wilhelms-Universität Bonn, Dortmund, Germany.
Obesity (Silver Spring). 2008 Feb;16(2):389-95. doi: 10.1038/oby.2007.57.
To investigate the effect of breastfeeding in healthy boys and girls on their trajectories of percent body fat (%BF) and BMI standard deviation scores (BMI-SDS) throughout childhood.
Analyses of the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study included data from 219 male and 215 female term participants, born between 1984 and 1999, with repeated anthropometric measurements between 0.5 and 7 years and prospective data on duration of breastfeeding.
Among boys with an overweight mother (OW-M), analyses adjusted for potential confounders revealed that not or shortly breastfed (< or =17 weeks) boys did not experience the age-dependent decrease in %BF seen in all children with normal weight mothers (NW-Ms). In contrast, boys fully breastfed for >17 weeks were protected against the adverse effect of maternal overweight (effect of long breastfeeding vs. no/short breastfeeding among boys with OW-Ms: 0.46%/year; s.e. 0.18; P = 0.01). There was also a suggestion of an interaction between maternal overweight and breastfeeding for the BMI-SDS trajectory (0.08 SDS/year; s.e. 0.04; P = 0.07). Among boys with NW-Ms mothers and the corresponding subgroups of girls, breastfeeding had little effect on the development of %BF or BMI-SDS throughout childhood.
Our study suggests that breastfeeding could offset a potential programming effect for childhood adiposity among boys with OW-Ms, to whom advice to breast-feed should thus be specifically targeted.
研究母乳喂养对健康男孩和女孩整个童年期体脂百分比（%BF）轨迹及体重指数标准差评分（BMI-SDS）的影响。
多特蒙德营养与人体测量纵向设计（DONALD）研究分析纳入了219名男性和215名女性足月儿的数据，这些儿童出生于1984年至1999年之间，在0.5至7岁期间进行了多次人体测量，并收集了母乳喂养持续时间的前瞻性数据。
在母亲超重（OW-M）的男孩中，经潜在混杂因素调整后的分析显示，未进行母乳喂养或母乳喂养时间短（≤17周）的男孩，并未出现所有体重正常母亲（NW-M）的孩子随年龄增长%BF下降的情况。相比之下，母乳喂养超过17周的男孩可免受母亲超重的不利影响（OW-M男孩中长时间母乳喂养与未进行/短时间母乳喂养的效果对比：每年0.46%；标准误0.18；P = 0.01）。对于BMI-SDS轨迹，也存在母亲超重与母乳喂养之间相互作用的迹象（每年0.08 SDS；标准误0.04；P = 0.07）。在NW-M母亲的男孩及相应的女孩亚组中，母乳喂养对整个童年期%BF或BMI-SDS的发展影响不大。
我们的研究表明，母乳喂养可以抵消OW-M男孩童年肥胖的潜在编程效应，因此应特别针对这类男孩提供母乳喂养建议。
