van den Berg Manon G A, Rasmussen-Conrad Ellen L, van Nispen Lillian, van Binsbergen Jaap J, Merkx Matthias A W
Department of Dietetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Oral Oncol. 2008 Sep;44(9):830-7. doi: 10.1016/j.oraloncology.2007.11.002. Epub 2008 Feb 20.
The objective of this observational prospective study in patients with squamous cell carcinoma (SCC) of the oral, oropharyngeal and hypopharyngeal cavity was to look into the relation between malnutrition (>or=10% unintended weight loss within 6 months) and specific quality of life (QoL) parameters longitudinally. Bodyweight and QoL were monitored in 47 patients with SCC at diagnosis, end of treatment and six months after treatment. EORTC QoLQ-C30 and H&N 35 questionnaires were used to assess QoL. Significantly lower scores on the global QoL during treatment (p=0.01) and revalidation (p=0.02) were found for patients who had lost >or=10% compared to patients with <10% loss of weight within 6 month. Patients with radiotherapy and a treatment modality of radiotherapy with surgery or chemotherapy kept their unintended weight loss until the end of treatment. Patients with head and neck cancer treated with radiotherapy are specifically susceptible to malnutrition during treatment with no improvement in body weight or QoL. Professional preventive nutritional support is therefore already required on diagnoses.
这项针对口腔、口咽和下咽鳞状细胞癌（SCC）患者的前瞻性观察研究的目的是纵向研究营养不良（6个月内非故意体重减轻≥10%）与特定生活质量（QoL）参数之间的关系。在47例SCC患者诊断时、治疗结束时和治疗后6个月监测体重和生活质量。使用欧洲癌症研究与治疗组织（EORTC）生活质量问卷Q-C30和头颈部问卷H&N 35评估生活质量。与6个月内体重减轻<10%的患者相比，体重减轻≥10%的患者在治疗期间（p=0.01）和复查时（p=0.02）的总体生活质量得分显著更低。接受放疗以及放疗联合手术或化疗治疗方式的患者在治疗结束前一直存在非故意体重减轻。接受放疗的头颈癌患者在治疗期间特别容易出现营养不良，体重和生活质量均无改善。因此，在诊断时就需要专业的预防性营养支持。
