大肠杆菌的ygaVP基因构成一个三丁基锡诱导型操纵子。
The ygaVP genes of Escherichia coli form a tributyltin-inducible operon.
作者信息
Gueuné Hervé, Durand Marie-José, Thouand Gérald, DuBow Michael S
机构信息
Université de Nantes, CNRS UMR 6144, GEPEA, ERT CBAC, Département Génie Biologique, 18 Bd. Gaston Defferre, 85035 La Roche sur Yon, France.
出版信息
Appl Environ Microbiol. 2008 Mar;74(6):1954-8. doi: 10.1128/AEM.02294-07. Epub 2008 Feb 1.
Abstract
A tributyltin (TBT) luxAB transcriptional fusion in Escherichia coli revealed that a TBT-activated promoter is located upstream of two cotranscribed orphan genes, ygaV and ygaP. We demonstrate that transcription from the promoter upstream of ygaVP is constitutive in a ygaVP mutant, suggesting that YgaV is an autoregulated, TBT-inducible repressor.
摘要
在大肠杆菌中构建的三丁基锡（TBT）luxAB转录融合体显示，一个TBT激活的启动子位于两个共转录的孤儿基因ygaV和ygaP的上游。我们证明，在ygaVP突变体中，ygaVP上游启动子的转录是组成型的，这表明YgaV是一种自我调节的、TBT诱导的阻遏物。
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2
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