Mandelker Lester
Community Veterinary Hospital, 1631 West Bay Drive, Largo, FL 33770, USA.
Vet Clin North Am Small Anim Pract. 2008 Jan;38(1):1-30, v. doi: 10.1016/j.cvsm.2007.10.005.
Oxidative stress and mitochondrial dysfunction are discussed in this article. Mitochondria are the major producers of free radicals and the major target of oxidative damage. Oxidative stress is simply the elevation of free radicals (reactive oxygen species/reactive nitrogen species) found in cells that accumulate to higher than normal levels. Excessive or inappropriate oxidative stress damages cells and tissues, specifically mitochondria, cell membranes, DNA, proteins, and lipids.
本文讨论了氧化应激和线粒体功能障碍。线粒体是自由基的主要产生者和氧化损伤的主要靶点。氧化应激仅仅是细胞中发现的自由基（活性氧/活性氮）升高，其积累高于正常水平。过度或不适当的氧化应激会损害细胞和组织，特别是线粒体、细胞膜、DNA、蛋白质和脂质。
