Cannavó Serafinella Patrizia, Borgia Francesco, Adamo Barbara, Guarneri Biagio
Department of Territorial Social Medicine, Section of Dermatology, University of Messina, Messina, Italy.
J Am Acad Dermatol. 2008 Apr;58(4):657-60. doi: 10.1016/j.jaad.2007.12.030. Epub 2008 Feb 6.
Disseminated superficial porokeratosis has been described in the setting of immunosuppressive conditions, including organ transplantation, infections, and hematopoietic malignancies. The outbreak of disseminated superficial porokeratosis during the development of solid organ malignancies has been rarely reported in the literature in patients affected by hepatitis C virus-related hepatocellular carcinoma or by cholangiocarcinoma, which suggests a paraneoplastic nature of the cutaneous disease. We report an unusual case of disseminated superficial porokeratosis in a patient affected by ovarian cancer, characterized by simultaneous onset and a parallel course of the two pathologies; there was good clinical response to chemotherapy, accompanied by a successful stop of disseminated superficial porokeratosis progression and gradual clearing of the keratotic lesions.
播散性浅表性汗孔角化症已在免疫抑制状态下被描述，包括器官移植、感染和血液系统恶性肿瘤。实体器官恶性肿瘤发生过程中播散性浅表性汗孔角化症的爆发，在丙型肝炎病毒相关肝细胞癌或胆管癌患者的文献中鲜有报道，这提示了这种皮肤疾病的副肿瘤性质。我们报告了一例卵巢癌患者发生播散性浅表性汗孔角化症的罕见病例，其特征为两种病症同时出现且病程平行；化疗后临床反应良好，同时成功阻止了播散性浅表性汗孔角化症的进展，角化性皮损逐渐消退。
