Nojima Y, Terai C, Minota S, Takano K, Miyakawa Y, Takaku F
Clin Immunol Immunopathol. 1985 Jan;34(1):109-17. doi: 10.1016/0090-1229(85)90013-3.
Erythrocytes from 51 patients with systemic lupus erythematosus and 75 controls were tested for the capacity to bind aggregated human gamma-globulin labeled with radioiodine in the presence of complement. Both in patients and controls, a trimodal distribution of binding capacity was observed. Low (less than 9% of the added radioactivity), intermediate (9-17%), and high binding (more than 17%) were observed in 13, 58, and 29% in controls and in 49, 43 and 8% in lupus patients. The low binding capacity of erythrocytes persisted even after patients entered remission following steroid therapy. A genetic control of binding capacity was supported by familial surveys. Prevalence of pathological proteinuria was significantly higher in patients with low binding capacity than those with intermediate or high binding capacity (16/25 vs 7/26, P less than 0.01). These results indicate that an impaired physiological disposal of immune complexes via the erythrocyte C3b receptor in lupus patients may contribute to the development of renal involvement.
对51例系统性红斑狼疮患者和75例对照者的红细胞进行检测，以评估其在补体存在的情况下结合用放射性碘标记的聚合人γ-球蛋白的能力。在患者和对照者中，均观察到结合能力呈三峰分布。在对照者中，低结合能力（低于添加放射性的9%）、中等结合能力（9%-17%）和高结合能力（超过17%）分别见于13%、58%和29%的人群；在狼疮患者中，上述比例分别为49%、43%和8%。即使在患者接受类固醇治疗进入缓解期后，红细胞的低结合能力依然存在。家族调查支持结合能力存在遗传控制。低结合能力患者病理性蛋白尿的患病率显著高于中等或高结合能力患者（16/25 vs 7/26，P<0.01）。这些结果表明，狼疮患者中通过红细胞C3b受体对免疫复合物的生理性清除受损可能促使肾脏受累的发生。
