Salonen J T, Salonen R, Seppänen K, Rinta-Kiikka S, Kuukka M, Korpela H, Alfthan G, Kantola M, Schalch W
Department of Community Health and General Practice, University of Kuopio, Finland.
Am J Clin Nutr. 1991 May;53(5):1222-9. doi: 10.1093/ajcn/53.5.1222.
We investigated the effect on platelet function of supplementing men with low antioxidant status with 600 mg ascorbic acid, 300 mg alpha-tocopherol, 27 mg beta-carotene, and 75 micrograms selenium in yeast daily. Eighty men were randomly assigned in pairs (matched for smoking, baseline antioxidant status, and time and day of entry) by use of a double-blind design to receive supplement or placebo for 5 mo. Compared with 39 control subjects, 39 antioxidant-supplemented men experienced the following net reductions during the double-blind period: 20% (P = 0.012) in serum lipid peroxides, 24% (P = 0.035) in ADP-induced platelet aggregation, 42% (P = 0.040) in the rate of ATP release during aggregation, 51% (P = 0.018) in serum (platelet-produced) thromboxane B2, and 29% (P = 0.024) in plasma beta-thromboglobulin concentration. The data support our hypothesis that antioxidant supplementation of men with low antioxidant status and high fat intake reduces lipid peroxidation, the capacity of platelets to aggregate and to produce thromboxane A2, and in vivo platelet activation.
我们研究了每日给抗氧化状态较低的男性补充600毫克抗坏血酸、300毫克α-生育酚、27毫克β-胡萝卜素和75微克酵母硒对血小板功能的影响。采用双盲设计，将80名男性按配对随机分组（根据吸烟情况、基线抗氧化状态以及入组时间和日期进行匹配），接受补充剂或安慰剂治疗5个月。与39名对照受试者相比，39名补充抗氧化剂的男性在双盲期出现了以下净降低情况：血清脂质过氧化物降低20%（P = 0.012），ADP诱导的血小板聚集降低24%（P = 0.035），聚集过程中ATP释放速率降低42%（P = 0.040），血清（血小板产生的）血栓素B2降低51%（P = 0.018），血浆β-血小板球蛋白浓度降低29%（P = 0.024）。这些数据支持了我们的假设，即给抗氧化状态低且脂肪摄入量高的男性补充抗氧化剂可减少脂质过氧化、血小板聚集和产生血栓素A2的能力以及体内血小板激活。
