Philip B K, Scott D A, Freiberger D, Gibbs R R, Hunt C, Murray E
Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Can J Anaesth. 1991 Mar;38(2):183-6. doi: 10.1007/BF03008141.
Butorphanol was compared with fentanyl as the narcotic component of general anaesthesia for ambulatory laparoscopic surgery. This double-blind, randomized study enrolled 60 healthy women who received equianalgesic doses of fentanyl 1 microgram.kg-1 (F, n = 30) or butorphanol 20 micrograms.kg-1 (B, n = 30) prior to induction of anaesthesia. Tracheal anaesthesia was maintained with nitrous oxide/oxygen, isoflurane, and succinylcholine by infusion. Intraoperatively, patients who received B demonstrated lower pulse rate before and after intubation (P less than 0.05, P less than 0.01) and lower diastolic blood pressure after intubation (P less than 0.01). Anesthesiologists judged the maintenance phase as satisfactory more often with B (P less than 0.05). Postoperatively, there were no differences in analgesic need. No major side-effects occurred in either group. Among minor side-effects, patients who received B reported postoperative sedation more often, 77% vs 37% (P less than 0.01), which occurred during the first 45 min of recovery (P less than 0.05). Discharge times were not different. On the first postoperative day, more subjects who received B were satisfied with their anaesthesia experience (P less than 0.05). Butorphanol 20 micrograms.kg-1 is an acceptable alternative analgesic in general anaesthesia for ambulatory laparoscopy.
将布托啡诺与芬太尼作为门诊腹腔镜手术全身麻醉的麻醉成分进行比较。这项双盲随机研究纳入了60名健康女性，她们在麻醉诱导前接受了等效镇痛剂量的1微克·千克⁻¹芬太尼（F组，n = 30）或20微克·千克⁻¹布托啡诺（B组，n = 30）。通过输注氧化亚氮/氧气、异氟烷和琥珀酰胆碱维持气管内麻醉。术中，接受布托啡诺的患者插管前后心率较低（P < 0.05，P < 0.01），插管后舒张压较低（P < 0.01）。麻醉医生认为使用布托啡诺时维持期更满意（P < 0.05）。术后，镇痛需求无差异。两组均未发生重大副作用。在轻微副作用方面，接受布托啡诺的患者术后镇静发生率更高，为77% 对37%（P < 0.01），且发生在恢复的前45分钟内（P < 0.05）。出院时间无差异。术后第一天，更多接受布托啡诺的受试者对其麻醉体验感到满意（P < 0.05）。20微克·千克⁻¹布托啡诺是门诊腹腔镜手术全身麻醉中一种可接受的替代镇痛药。
