Ahn Yong Min, Chang Jaeseung, Joo Yeon Ho, Kim Seong Chan, Lee Kyu Young, Kim Yong Sik
Department of Psychiatry and Behavioral Science and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Bipolar Disord. 2008 Mar;10(2):271-5. doi: 10.1111/j.1399-5618.2007.00573.x.
Although a broad range of circadian rhythm variations have been reported, analyses of chronotypes in bipolar I disorder (BDI) and schizophrenia are rare. The present study aimed to investigate specific chronotype patterns in BDI and schizophrenia compared with healthy subjects.
All patients were clinically stable and recruited from the outpatient clinics of Seoul National University Hospital. They were diagnosed according to DSM-IV criteria. 'Morningness/eveningness', a chronotype correlated with circadian phase, was evaluated using the Composite Scale of Morningness (CSM) among 92 patients with BDI, 113 patients with schizophrenia (SZ), and 95 control individuals.
The CSM scores were significantly correlated with age in the control group, but a significant correlation with age was not observed in the schizophrenia or BDI groups. After controlling for age, there were significant differences between the BDI and control groups. The SZ patients did not differ from the BDI or control groups.
In this Korean sample, patients with BDI showed a significantly greater preference for 'eveningness' (including delayed sleep timing) than control individuals. The influences of pharmacotherapy or clinical status on CSM scores need to be clarified.
尽管已经报道了广泛的昼夜节律变化，但对双相I型障碍（BDI）和精神分裂症的昼夜类型分析却很少见。本研究旨在调查BDI和精神分裂症患者与健康受试者相比的特定昼夜类型模式。
所有患者临床症状稳定，均来自首尔国立大学医院门诊。他们根据《精神疾病诊断与统计手册》第四版标准进行诊断。使用晨型综合量表（CSM）对92例BDI患者、113例精神分裂症（SZ）患者和95名对照个体进行了与昼夜节律相关的“晨型/夜型”评估。
对照组中CSM得分与年龄显著相关，但在精神分裂症或BDI组中未观察到与年龄的显著相关性。在控制年龄后，BDI组与对照组之间存在显著差异。SZ患者与BDI组或对照组无差异。
在这个韩国样本中，BDI患者比对照个体表现出对“夜型”（包括延迟睡眠时间）明显更大的偏好。药物治疗或临床状态对CSM得分的影响需要进一步阐明。
