Padmanabhan V, Siefert K, Ransom S, Johnson T, Pinkerton J, Anderson L, Tao L, Kannan K
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109-0404, USA.
J Perinatol. 2008 Apr;28(4):258-63. doi: 10.1038/sj.jp.7211913. Epub 2008 Feb 14.
The objective was to determine whether bisphenol-A (BPA) is found in maternal circulation of pregnant women in the US population and is related to gestational length and birth weight.
Circulating levels of BPA were quantified by high performance liquid chromatography-tandem mass spectrometry at delivery in 40 southeastern Michigan mothers and correlated with gestational length and birth weight of offspring.
Maternal levels of unconjugated BPA ranged between 0.5 and 22.3 ng ml(-1) in southeastern Michigan mothers. There was no correlation between BPA concentrations and gestational length or birth weight of offspring.
This is the first study to document measurable levels of BPA in maternal blood of the US population. Long-term follow-up studies of offspring are needed to validate or refute concerns over human fetal exposure to synthetic exogenous steroids.
确定在美国人群中,孕妇母体循环中是否存在双酚A(BPA),以及其是否与妊娠期长度和出生体重有关。
采用高效液相色谱-串联质谱法对密歇根州东南部40名母亲分娩时的BPA循环水平进行定量,并将其与后代的妊娠期长度和出生体重进行关联分析。
密歇根州东南部母亲体内未结合BPA的水平在0.5至22.3 ng/ml之间。BPA浓度与后代的妊娠期长度或出生体重之间无相关性。
这是第一项记录美国人群母体血液中可测量水平BPA的研究。需要对后代进行长期随访研究,以证实或反驳关于人类胎儿暴露于合成外源性类固醇的担忧。